Association between Type-2 Diabetes Mellitus and Infection by Human Papillomavirus Genotype-18 in Women Aged 40-44 Years Old
Daniel Lopez-Hernandez *
Quality Management Coordination, Family Medicine Clinic “Division del Norte”, The Security Institute and Workers’ Social Services of the State, North Division Avenue Number 3755, San Pablo Tepetlapa, Coyoacan, C.P. 04840, Mexico City, Mexico.
Tania Castillo-Cruz
Medical Coordination, Family Medicine Clinic “Division del Norte”, The Security Institute and Workers’ Social Services of the State, North Division Avenue Number 3755, San Pablo Tepetlapa, Coyoacan, C.P. 04840, Mexico City, Mexico.
Leticia Brito-Aranda
Centro de Investigacion y Educacion Continua, S.C. La Perla, Nezahualcoyotl, C.P. 57820, Mexico State, Mexico.
Luis Beltran-Lagunes
Teaching and Research Service, Family Medicina Clinic “Gustavo A. Madero”, The Security Institute and Workers’ Social Services of the State, Calzada Guadalupe Number 712, Tepeyac Insurgentes, Gustavo A. Madero, C.P. 07020, Mexico City, Mexico.
Nadhyieli Orozco-Campos
Physician, Family Medicina Clinic “Narvarte”, The Security Institute and Workers’ Social Services of the State, Eugenia Street Number 230, Narvarte Poniente, Benito Juraez, C.P. 03020, Mexico City, Mexico.
Emanuel Melgarejo-Estefan
Health Regulations Directorate, The Security Institute and Workers’ Social Services of the State, San Fernando Avenue Number 547, San Fernando, Tlalpan, C.P. 14070, Mexico City, Mexico.
*Author to whom correspondence should be addressed.
Abstract
Objective: To analyze the prevalence and incidence of Human Papillomavirus (HPV) infection and its possible association with type 2 diabetes mellitus.
Materials and Methods: A retrospective cohort study was conducted. Exposure was HPV-infection.
Results: 13234 females were analyzed [median of age=46], 1215 cases of diabetes (median of age=53) and 12019 cases without diabetes (median of age=45). There were 1495 (11.3%; 95%CI 10.8–11.8) new cases of HPV infection by any genotype, 234 (1.8%; 95%CI 1.5–2.0) by genotype-16, 102 (0.8%; 95%CI 0.8–0.8) by genotype-18, and 1279 (9.7%; 95%CI 9.2–10.1) by high risk (HR) genotypes. The global crude-prevalence by any genotype, and HR-genotypes was significantly lower (p=0.008) in subjects with diabetes compared with their counterparts without diabetes. The mean duration of follow-up was 1.1 years. The global crude-incidence rate of HPV-infection per 1000 person-years by any genotype, and genotypes-16, - 18, and -HR was 99.36, 15.55, 6.78, and 85.01, respectively. The crude hazard ratio of infection by HPV-18 genotype was higher in women with diabetes and age between 20-24y (HR=36.611; 95%CI 4.009-334.303, p=0.001), and 40-44y (HR=3.947; 95%CI 1.124-13.857, p=0.032) compared with their counterparts without diabetes.
Conclusion: Type 2 diabetes mellitus increases the risk of infection by HPV-genotype-18 in young adult woman.
Keywords: Human papillomavirus infection, human papillomavirus genotypes, diabetes mellitus