Electrostatic Attraction: Inhibitory-mechanism of The Medicinal Synthetic Aluminum-magnesium silicate against Electrically Charged Disease-agents (Human immune deficiency virus/Cancer-cells/Other viruses/Infected cells) and the Medicine`s Adjuvant Effects

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Maduike C. O. Ezeibe
Mary E. Sanda
Ijeoma J. Ogbonna
Ekenma Kalu
Njoku U. Njoku

Abstract

Aim: To review mechanisms of actions of The medicinal synthetic Aluminum-magnesium silicate (MSAMS) as, antiviral, antiretroviral and anticancer medicine and as adjuvant.

Materials and Methods: Literature-review for information on Aluminum-magnesium silicate (AMS) as a pharmaceutical binder/stabilizing agent and results of experiments on effects of electrostatic attraction, between AMS-Nanoparticles and opposite electrical charges, on disease-agents.

Findings: AMS is traditionally a pharmaceutical binder for drug-formulations. It binds medicines because its molecular Nanoparticles have negatively charged surfaces and positively charged edges. Viruses and abnormal cells (cancer and infected) are also electrically charged. So, AMS bonds to the disease-agents by opposite-charges` electrostatic attractions.  For that reason, it has antiviral and anticancer effects. As a silicate, it stimulates immunity.  It is also a stabilizing agent. Stabilizing medicines prolongs bioavailability. Again, Nanoparticles deliver drugs to targets.  Prolonging bioavailability and improving delivery enhance efficacy of antimicrobials. Enhancing efficacy leads to enough clearance of infections so that immunity completes their termination to prevent development of drug-resistance. Enhancing efficacy of antimicrobials also reduces their doses, needed to achieve desired effects, thus reducing side effects of drugs, to further enhance patients` immune responses. Synergy between enhanced efficacy of medicines and enhanced patients` immunity, leads to clearance of resistant secondary infections and termination of viral infections. By reducing doses of drugs, concentrations of their active ingredients in formulations are reduced thus minimizing their cost. AMS is not found in every county and even in countries where it is found, it contains impurities. So it requires purifying to make it safe. However, oxides and silicates of Aluminum and Magnesium are already approved medicines being used for treatments. So, Aluminum silicate was reacted with Magnesium silicate to get MSAMS: Al4 (SiO4)3 + 3Mg2SiO4 → 2Al2 Mg(SiO4)3.

Conclusion: MSAMS mops HIV/other viruses and cancer-cells. It normalizes immunity and improves efficacy of medicines. Synergy between these MSAMS-effects and immunity inhibits electrically charged disease-

Keywords:
Electrostatic bonding to viruses/cancer-cells, enhancing immunity, clearing secondary infections (drug-resistant/sensitive).

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How to Cite
Ezeibe, M. C. O., Sanda, M. E., Ogbonna, I. J., Kalu, E., & Njoku, N. U. (2018). Electrostatic Attraction: Inhibitory-mechanism of The Medicinal Synthetic Aluminum-magnesium silicate against Electrically Charged Disease-agents (Human immune deficiency virus/Cancer-cells/Other viruses/Infected cells) and the Medicine`s Adjuvant Effects. Current Journal of Applied Science and Technology, 27(4), 1-11. https://doi.org/10.9734/CJAST/2018/41491
Section
Review Article